Amifostine enhances the resistance of renal proximal tubular epithelial cells to cisplatin by upregulating PKM2

Objective To explore the molecular mechanism of amifostine in relieving cisplatin nephrotoxicity. Methods CCK-8 assay was used to detect the inhibitory effect of amifostine on cisplatin cytotoxicity in HK-2 and primary renal proximal tubular epithelial cells. The expression of PKM2 was analyzed by o...

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Bibliographic Details

Published in:	陆军军医大学学报
Main Authors:	XUE Rong, MA Jingang, LI Yingping, ZHANG Jian, GAO Peijuan
Format:	Article
Language:	Chinese
Published:	Editorial Office of Journal of Army Medical University 2023-03-01
Subjects:	amifostine renal proximal tubular epithelial cells pkm2 cisplatin toxicity
Online Access:	http://aammt.tmmu.edu.cn/html/202207159.htm