Nme2Cas9‐mediated therapeutic editing in inhibiting angiogenesis after wet age‐related macular degeneration onset

Abstract Background Age‐related macular degeneration (AMD), particularly wet AMD characterised by choroidal neovascularization (CNV), is a leading cause of vision loss in the elderly. The hypoxia‐inducible factor‐1α (HIF‐1α)/vascular endothelial growth factor (VEGF)/VEGF receptor 2 (VEGFR2) pathway...

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Bibliographic Details
Published in:Clinical and Translational Medicine
Main Authors: Sihui Hu, Yuxi Chen, Dongchun Xie, Kan Xu, Yunzhao Fu, Wei Chi, Haiying Liu, Junjiu Huang
Format: Article
Language:English
Published: Wiley 2023-08-01
Subjects:
choroidal neovascularization
gene editing
gene therapy
Nme2Cas9
wet AMD
Online Access:https://doi.org/10.1002/ctm2.1383

Internet

https://doi.org/10.1002/ctm2.1383

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