The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor

Abstract Background Transcription factor 4 (TCF4) is a member of the basic helix-loop-helix (bHLH) family of transcription factors that guides proper embryogenesis, particularly neurogenesis, myogenesis, heart development and hematopoiesis. The interaction of TCF4 with DNA is dependent on the presen...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Nikola Sozańska, Barbara P. Klepka, Anna Niedzwiecka, Lilia Zhukova, Michał Dadlez, Beata Greb-Markiewicz, Andrzej Ożyhar, Aneta Tarczewska
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	Transcription factor 4 (TCF4) Immunoglobulin transcription factor 2 (ITF2) SL3-3 enhancer factor 2 (SEF2) Basic helix-loop-helix (bHLH) Intrinsically disordered regions (IDRs) Intrinsically disordered proteins (IDPs)
Online Access:	https://doi.org/10.1186/s12964-025-02154-7