Collective dynamics underlying allosteric transitions in hemoglobin.

Hemoglobin is the prototypic allosteric protein. Still, its molecular allosteric mechanism is not fully understood. To elucidate the mechanism of cooperativity on an atomistic level, we developed a novel computational technique to analyse the coupling of tertiary and quaternary motions. From Molecul...

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Bibliographic Details
Published in:PLoS Computational Biology
Main Authors: Martin D Vesper, Bert L de Groot
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Online Access:http://europepmc.org/articles/PMC3777908?pdf=render