Menstrual blood-derived endometrial stem cells ameliorate neuroinflammation and apoptosis through JAK2/STAT3 signaling pathway in NPC1 mutant cell and mice

Abstract Background Niemann-Pick disease type C1 (NPC1) is caused by NPC1 gene mutations, resulting in Purkinje cell degeneration and death, glial cell activation, and progressive neurodegeneration. Menstrual blood-derived endometrial stem cells (MenSCs) have been explored as a promising tool for tr...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Lihong Guan, Keli Xu, Minlin Yang, Yangyang Li, Xiaoying Li, Han Li, Ciqing Yang, Liang Qiao, Yanli Liu, Zisen Jia, Jinghui Wei, Fen Yang, Juntang Lin
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Subjects:	Mesenchymal stem cells Niemann-Pick disease type C1 Unesterified cholesterol Neuroinflammation Purkinje cell
Online Access:	https://doi.org/10.1186/s13287-025-04575-0