Phenotypic Switching of Vascular Smooth Muscle Cells in Atherosclerosis

The medial layer of the arterial wall is composed mainly of vascular smooth muscle cells (VSMCs). Under physiological conditions, VSMCs assume a contractile phenotype, and their primary function is to regulate vascular tone. In contrast with terminally differentiated cells, VSMCs possess phenotypic...

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Bibliographic Details

Published in:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Main Authors:	Runji Chen, David G. McVey, Daifei Shen, Xiaoxin Huang, Shu Ye
Format:	Article
Language:	English
Published:	Wiley 2023-10-01
Subjects:	atherosclerosis cell lineage dedifferentiation phenotypes vascular smooth muscle cells
Online Access:	https://www.ahajournals.org/doi/10.1161/JAHA.123.031121