Establishment of a sensitive UPLC-MS/MS method to quantify safinamide in rat plasma

A fast, simple, and sensitive ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was established for the quantification of safinamide in rat plasma. Plasma samples were treated with acetonitrile for protein precipitation, and diazepam was used as an internal standar...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Ying Wang, Guan-An Zhao, Xia Li, En Zhang, Wei Tan, Jia-qi Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-08-01
Subjects:	UPLC-MS/MS rat safinamide plasma pharmacokinetics
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1211383/full