CD147 regulates the Rap1 signaling pathway to promote proliferation, migration, and invasion, and inhibit apoptosis in colorectal cancer cells

Abstract The malignant progression of colorectal cancer (CRC) is intimately associated with the abnormal regulation of transmembrane glycoprotein CD147. However, the molecular mechanism via the Rap1/Rap1GAP signaling axis has not been elucidated. This study, through integrated bioinformatics analysi...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Fu Xiaoxia, Li Rui, Chen Meiru, Yuan Lu, Jin Ying
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Subjects:
Colorectal cancer
CD147
Rap1/Rap1GAP signaling pathway
Apoptosis
Epithelial-mesenchymal transition (EMT)
Online Access:https://doi.org/10.1038/s41598-025-98266-8

Internet

https://doi.org/10.1038/s41598-025-98266-8

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