The CMV-encoded G protein-coupled receptors M33 and US28 play pleiotropic roles in immune evasion and alter host T cell responses

IntroductionHuman cytomegalovirus (HCMV) is a global health threat due to its ubiquity and lifelong persistence in infected people. During latency, host CD8+ T cell responses to HCMV continue to increase in a phenomenon known as memory inflation. We used murine CMV (MCMV) as a model for HCMV to char...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Timothy M. White, Cassandra M. Bonavita, Brent A. Stanfield, Helen E. Farrell, Nicholas J. Davis-Poynter, Rhonda D. Cardin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Subjects:	Cytomegalovirus (CMV) viral latency T cell memory memory inflation Viral G protein-coupled receptor
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1047299/full