Tailor-made 3D in vitro maturation of early antral follicles uncovers cumulus-cell transcriptomic driver signature to predict oocyte competence

BackgroundAssisted reproductive technologies (ART) are constrained by the limited pool of medium antral follicles. Early antral follicles (EAfs) are an emerging additional source coming either from cryopreserved ovaries or from in vitro folliculogenesis protocols. The EAfs have the advantage of bein...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Camila Rojo-Fleming, Fani Konstantinidou, Alessia Peserico, Chiara Di Berardino, Giulia Capacchietti, Delia Nardinocchi, Chiara Camerano Spelta Rapini, Valentina Russo, Nicola Bernabò, Antonio Capalbo, Liborio Stuppia, Valentina Gatta, Barbara Barboni
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	cumulus cells transcriptome ovine oocyte competence differentially expressed genes (DEGs) highly interconnected genes (HUBs) follicle – enclosed oocyte in vitro maturation (FEO-IVM)
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2025.1629815/full