The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay

Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a series of quality control events including ribosome rescue, degradation of the stalled nascent polypeptide, and targeting of the mRNA for decay (No Go Decay or NGD). Using a reverse genetic screen in yeast, we...

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Bibliographic Details

Published in:	eLife
Main Authors:	Karole N D'Orazio, Colin Chih-Chien Wu, Niladri Sinha, Raphael Loll-Krippleber, Grant W Brown, Rachel Green
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2019-06-01
Subjects:	No Go Decay endonuclease mRNA ubiquitin
Online Access:	https://elifesciences.org/articles/49117