An Enhanced Dissolving Cyclosporin-A Inhalable Powder Efficiently Reduces SARS-CoV-2 Infection In Vitro

This work illustrates the development of a dry inhalation powder of cyclosporine-A for the prevention of rejection after lung transplantation and for the treatment of COVID-19. The influence of excipients on the spray-dried powder’s critical quality attributes was explored. The best-performing powde...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Davide D’Angelo, Eride Quarta, Stefania Glieca, Giada Varacca, Lisa Flammini, Simona Bertoni, Martina Brandolini, Vittorio Sambri, Laura Grumiro, Giulia Gatti, Giorgio Dirani, Francesca Taddei, Annalisa Bianchera, Fabio Sonvico, Ruggero Bettini, Francesca Buttini
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Subjects:	cyclosporine-A spray-drying dry powder inhaler SARS-CoV-2 cytokine storm transplant rejection
Online Access:	https://www.mdpi.com/1999-4923/15/3/1023