The Inhibition of CDK8/19 Mediator Kinases Prevents the Development of Resistance to EGFR-Targeting Drugs

Drug resistance is the main obstacle to achieving cures with both conventional and targeted anticancer drugs. The emergence of acquired drug resistance is initially mediated by non-genetic transcriptional changes, which occur at a much higher frequency than mutations and may involve population-scale...

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Bibliographic Details

Published in:	Cells
Main Authors:	Amanda C. Sharko, Chang-Uk Lim, Martina S. J. McDermott, Chuck Hennes, Kingsavanh P. Philavong, Tiffanie Aiken, Victor V. Tatarskiy, Igor B. Roninson, Eugenia V. Broude
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Subjects:	CDK8 CDK19 EGFR gefitinib erlotinib cetuximab
Online Access:	https://www.mdpi.com/2073-4409/10/1/144