The Inhibition of CDK8/19 Mediator Kinases Prevents the Development of Resistance to EGFR-Targeting Drugs

Drug resistance is the main obstacle to achieving cures with both conventional and targeted anticancer drugs. The emergence of acquired drug resistance is initially mediated by non-genetic transcriptional changes, which occur at a much higher frequency than mutations and may involve population-scale...

詳細記述

書誌詳細

出版年:	Cells
主要な著者:	Amanda C. Sharko, Chang-Uk Lim, Martina S. J. McDermott, Chuck Hennes, Kingsavanh P. Philavong, Tiffanie Aiken, Victor V. Tatarskiy, Igor B. Roninson, Eugenia V. Broude
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2021-01-01
主題:	CDK8 CDK19 EGFR gefitinib erlotinib cetuximab
オンライン･アクセス:	https://www.mdpi.com/2073-4409/10/1/144