Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice

Osteoporosis is a systemic metabolic skeletal disease characterized by low bone mass and strength associated with fragility fractures. Oxidative stress, which results from elevated intracellular reactive oxygen species (ROS) and arises in the aging organism, is considered one of the critical factors...

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Bibliographic Details

Published in:	Disease Models & Mechanisms
Main Authors:	Astrid M. Schoppa, Xiangxu Chen, Jan-Moritz Ramge, Anna Vikman, Verena Fischer, Melanie Haffner-Luntzer, Jana Riegger, Jan Tuckermann, Karin Scharffetter-Kochanek, Anita Ignatius
Format:	Article
Language:	English
Published:	The Company of Biologists 2022-05-01
Subjects:	skeletal aging osteoporosis mitochondrial dysfunction reactive oxygen species senescence
Online Access:	http://dmm.biologists.org/content/15/5/dmm049392