Phosphomimetic Dicer S1016E triggers a switch to glutamine metabolism in gemcitabine-resistant pancreatic cancer

Objective: Dicer is an enzyme that processes microRNAs (miRNAs) precursors into mature miRNAs, which have been implicated in various aspects of cancer progressions, such as clinical aggressiveness, prognosis, and survival outcomes. We previously showed that high expression of Dicer is associated wit...

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Bibliographic Details

Published in:	Molecular Metabolism
Main Authors:	Ji Min Park, Jei-Ming Peng, Yu-Shiuan Shen, Chia-Ying Lin, Tung-Wei Hsu, Yen-Hao Su, Hsin-An Chen, Charupong Saengboonmee, Jung-Su Chang, Ching-Feng Chiu, Yan-Shen Shan
Format:	Article
Language:	English
Published:	Elsevier 2022-11-01
Subjects:	Dicer phosphorylation Pancreatic ductal adenocarcinoma Gemcitabine resistance Glutamine metabolism miRNA biogenesis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877822001454