Genome-wide methylation profiling reveals extracellular vesicle DNA as an ex vivo surrogate of cancer cell-derived DNA

Abstract Extracellular vesicle-derived DNA (evDNA) encapsulates the complete genome and mutational status of cells; however, whether cancer cell-derived evDNA mirrors the epigenetic features of parental genomic DNA remains uncertain. This study aimed to assess and compare the DNA methylation pattern...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Kyung-A Kim, Sunmin Kim, Inbal Wortzel, Suho Lee, Yoon Dae Han, Tae-Min Kim, Han Sang Kim
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-10-01
Subjects:	DNA methylation Extracellular vesicles Exosome EV-DNA Epigenetic modifications Cancer
Online Access:	https://doi.org/10.1038/s41598-024-75287-3