Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells

Objective: The transcription factors (TF) Foxa2 and Pdx1 are key regulators of beta-cell (β-cell) development and function. Mutations of these TFs or their respective cis-regulatory consensus binding sites have been linked to maturity diabetes of the young (MODY), pancreas agenesis, or diabetes susc...

Full description

Bibliographic Details
Published in:	Molecular Metabolism
Main Authors:	Aimée Bastidas-Ponce, Sara S. Roscioni, Ingo Burtscher, Erik Bader, Michael Sterr, Mostafa Bakhti, Heiko Lickert
Format:	Article
Language:	English
Published:	Elsevier 2017-06-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877817300510

Similar Items

NEUROD2 function is dispensable for human pancreatic β cell specification
by: Perla Cota, et al.
Published: (2023-10-01)

Genome-wide analysis of PDX1 target genes in human pancreatic progenitors
by: Xianming Wang, et al.
Published: (2018-03-01)

Point mutations in the PDX1 transactivation domain impair human β-cell development and function
by: Xianming Wang, et al.
Published: (2019-06-01)

Insulin regulates human pancreatic endocrine cell differentiation in vitro
by: Perla Cota, et al.
Published: (2024-01-01)

Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis
by: Mostafa Bakhti, et al.
Published: (2022-08-01)

Generation of ARX-T2A-H2B-CFP x C-PEP-mCherry-hiPSC double reporter line for monitoring of pancreatic differentiation
by: Eunike Sawitning Ayu Setyono, et al.
Published: (2025-04-01)

A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes
by: Nirav Florian Chhabra, et al.
Published: (2021-12-01)

Microarray analysis of <it>Foxa2 </it>mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives
by: Rossant Janet, et al.
Published: (2008-10-01)

FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation
by: Kihyun Lee, et al.
Published: (2019-07-01)

PDX1 is the cornerstone of pancreatic β-cell functions and identity
by: Nour Ebrahim, et al.
Published: (2022-12-01)

Foxa1 and Foxa2 are required for formation of the intervertebral discs.
by: Jennifer A Maier, et al.
Published: (2013-01-01)

Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function
by: Kathryn D. Henley, et al.
Published: (2016-06-01)

Cooperation between HMGA1, PDX-1 and MafA is essential for glucose-induced insulin transcription in pancreatic beta cells
by: Biagio eArcidiacono, et al.
Published: (2015-01-01)

FOXA1 and FOXA2: the regulatory mechanisms and therapeutic implications in cancer
by: Na Liu, et al.
Published: (2024-04-01)

Comparing the Expression of Foxa1 and Foxa2 Genes in the Stomach in Men and Women
by: Zahra Mohammadi, et al.
Published: (2015-11-01)

Regulation of Pdx1 by oxidative stress and Nrf2 in pancreatic beta-cells
by: Sharon Baumel-Alterzon, et al.
Published: (2022-09-01)

CFTR represses a PDX1 axis to govern pancreatic ductal cell fate
by: Pavana G. Rotti, et al.
Published: (2024-12-01)

FOXA1 in prostate cancer
by: Hui-Yu Dong, et al.
Published: (2023-01-01)

ASCL1 regulates and cooperates with FOXA2 to drive terminal neuroendocrine phenotype in prostate cancer
by: Shaghayegh Nouruzi, et al.
Published: (2025-07-01)

ASCL1 regulates and cooperates with FOXA2 to drive terminal neuroendocrine phenotype in prostate cancer
by: Shaghayegh Nouruzi, et al.
Published: (2025-08-01)

Two novel pathogenic PDX1 variants in two Japanese patients with maturity-onset diabetes of the young
by: Satoshi Tanaka, et al.
Published: (2025-05-01)

Targeting FOXA1 and FOXA2 disrupts the lineage-specific oncogenic output program in prostate cancer
by: Nicolo Formaggio, et al.
Published: (2025-10-01)

Development and Clinical Translation of Approved Gene Therapy Products for Genetic Disorders
by: Alireza Shahryari, et al.
Published: (2019-09-01)

Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2.
by: Irina M Bochkis, et al.
Published: (2012-01-01)

Transcriptomic characterization of postnatal muscle maturation
by: Alix Simon, et al.
Published: (2025-02-01)

Aberrant development of pancreatic beta cells derived from human iPSCs with FOXA2 deficiency
by: Ahmed K. Elsayed, et al.
Published: (2021-01-01)

Efficient growth suppression in pancreatic cancer PDX model by fully human anti-mesothelin CAR-T cells
by: Hua Jiang, et al.
Published: (2017-09-01)

Engrailed 1 deficiency induces changes in ciliogenesis during human neuronal differentiation
by: Sina Hembach, et al.
Published: (2024-05-01)

Chronic intermittent fasting impairs β cell maturation and function in adolescent mice
by: Leonardo Matta, et al.
Published: (2025-02-01)

Anticancer Effects of Fucoxanthin in a PDX Model of Advanced Stage Pancreatic Cancer with Alteration of Several Multifunctional Molecules
by: Masaru Terasaki, et al.
Published: (2023-09-01)

Pdx1 and Ngn3 overexpression enhances pancreatic differentiation of mouse ES cell-derived endoderm population.
by: Atsushi Kubo, et al.
Published: (2011-01-01)

Capturing heterogeneity in PDX models: representation matters
by: Hari Shankar Sunil, et al.
Published: (2024-05-01)

In-utero pancreatic cyst with postnatal resolution
by: Joseph G. Brungardt, et al.
Published: (2020-03-01)

Erythropoietin regulates developmental myelination in the brain stimulating postnatal oligodendrocyte maturation
by: Paola Muttathukunnel, et al.
Published: (2023-11-01)

PDX1 Binds and Represses Hepatic Genes to Ensure Robust Pancreatic Commitment in Differentiating Human Embryonic Stem Cells
by: Adrian Kee Keong Teo, et al.
Published: (2015-04-01)

Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1
by: Bushra Memon, et al.
Published: (2018-01-01)

Brachyury, Foxa2 and the cis-Regulatory Origins of the Notochord.
by: Diana S José-Edwards, et al.
Published: (2015-12-01)

Endometrial expression of FOX proteins (FOXA1 and FOXA2) in women of reproductive age with different endometrial thickness: prospective cohort comparative study
by: Natalia V. Aganezova, et al.
Published: (2023-10-01)

FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer
by: Soledad A Camolotto, et al.
Published: (2018-11-01)

Inceptor facilitates acrosomal vesicle formation in spermatids and is required for male fertility
by: Sara Bilekova, et al.
Published: (2023-08-01)