Inhibition of PDIs Downregulates Core LINC Complex Proteins, Promoting the Invasiveness of MDA-MB-231 Breast Cancer Cells in Confined Spaces In Vitro

Eukaryotic cells tether the nucleoskeleton to the cytoskeleton via a conserved molecular bridge, called the LINC complex. The core of the LINC complex comprises SUN-domain and KASH-domain proteins that directly associate within the nuclear envelope lumen. Intra- and inter-chain disulphide bonds, alo...

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Bibliographic Details

Published in:	Cells
Main Authors:	Natalie Young, Zizhao Gui, Suleiman Mustafa, Kleopatra Papa, Emily Jessop, Elizabeth Ruddell, Laura Bevington, Roy A. Quinlan, Adam M. Benham, Martin W. Goldberg, Boguslaw Obara, Iakowos Karakesisoglou
Format:	Article
Language:	English
Published:	MDPI AG 2024-05-01
Subjects:	intermediate filaments lamin LINC complex nesprins nuclear mechanics nucleus
Online Access:	https://www.mdpi.com/2073-4409/13/11/906