Increased UHMWPE Particle-Induced Osteolysis in Fetuin-A-Deficient Mice

Particle-induced osteolysis is a major cause of aseptic prosthetic loosening. Implant wear particles stimulate tissue macrophages inducing an aseptic inflammatory reaction, which ultimately results in bone loss. Fetuin-A is a key regulator of calcified matrix metabolism and an acute phase protein. W...

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Bibliographic Details

Published in:	Journal of Functional Biomaterials
Main Authors:	Christina Polan, Christina Brenner, Monika Herten, Gero Hilken, Florian Grabellus, Heinz-Lothar Meyer, Manuel Burggraf, Marcel Dudda, Willi Jahnen-Dechent, Christian Wedemeyer, Max Daniel Kauther
Format:	Article
Language:	English
Published:	MDPI AG 2023-01-01
Subjects:	implants arthroplasty aseptic prosthetic loosening osteolysis particle-induced osteolysis mouse calvaria osteolysis model
Online Access:	https://www.mdpi.com/2079-4983/14/1/30