Combinatorial activation of the WNT‐dependent fibrogenic program by distinct complement subunits in dystrophic muscle

Abstract Fibrosis is associated with compromised muscle functionality in Duchenne muscular dystrophy (DMD). We report observations with tissues from dystrophic patients and mice supporting a model to explain fibrosis in DMD, which relies on the crosstalk between the complement and the WNT signaling...

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Bibliographic Details

Published in:	EMBO Molecular Medicine
Main Authors:	Francesca Florio, Sara Vencato, Filomena T Papa, Michela Libergoli, Eyemen Kheir, Imen Ghzaiel, Thomas A Rando, Yvan Torrente, Stefano Biressi
Format:	Article
Language:	English
Published:	Springer Nature 2023-11-01
Subjects:	complement C1 complex Duchenne muscular dystrophy fibro‐adipogenic progenitors fibrosis skeletal muscle regeneration
Online Access:	https://doi.org/10.15252/emmm.202317405