Reassessing granzyme B: unveiling perforin-independent versatility in immune responses and therapeutic potentials

The pivotal role of Granzyme B (GzmB) in immune responses, initially tied to cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, has extended across diverse cell types and disease models. A number of studies have challenged conventional notions, revealing GzmB activity beyond apoptosis, im...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Raylynn Thompson, Xuefang Cao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-05-01
Subjects:	granzyme B perforin cytotoxic lymphocytes immune response inflammatory disorders
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1392535/full