Monopolar Spindle 1 Kinase (MPS1/TTK) mRNA Expression is Associated with Earlier Development of Clinical Symptoms, Tumor Aggressiveness and Survival of Glioma Patients

Inhibition of the protein kinase MPS1, a mitotic spindle-checkpoint regulator, reinforces the effects of multiple therapies against glioblastoma multiforme (GBM) in experimental settings. We analyzed <i>MPS1</i> mRNA-expression in gliomas WHO grade II, III and in clinical subgroups of GB...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Almuth F. Kessler, Jonas Feldheim, Dominik Schmitt, Julia J. Feldheim, Camelia M. Monoranu, Ralf-Ingo Ernestus, Mario Löhr, Carsten Hagemann
Format:	Article
Language:	English
Published:	MDPI AG 2020-07-01
Subjects:	glioblastoma multiforme low-grade glioma astrocytoma recurrence multifocal growth mRNA expression
Online Access:	https://www.mdpi.com/2227-9059/8/7/192