FCGR2/3 polymorphisms are associated with susceptibility to Kawasaki disease but do not predict intravenous immunoglobulin resistance and coronary artery aneurysms

IntroductionKawasaki disease (KD) is a pediatric vasculitis that can result in coronary artery aneurysm (CAA) formation, which is a dangerous complication. Treatment with intravenous immunoglobulin (IVIg) significantly decreases the risk of CAA, possibly through competitive binding to Fc-gamma recep...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Paula Uittenbogaard, Stejara A. Netea, Michael W. T. Tanck, Judy Geissler, Piotr Buda, Monika Kowalczyk-Domagała, Magdalena Okarska-Napierała, Diana van Stijn, Carline E. Tacke, US Kawasaki Disease Genetics Consortium, David P. Burgner, Chisato Shimizu, Jane C. Burns, Irene M. Kuipers, Taco W. Kuijpers, Sietse Q. Nagelkerke
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-09-01
Subjects:	Kawasaki disease IVIg CAA FCGR2 FCGR3 genetics
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1323171/full