Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 Protease

ABSTRACT The continuous emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) urges better understanding of the functional motifs in the spike (S) protein and their tolerance to mutations. Here, we focused on the S2′ motif, which, during virus entry, requires clea...

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Bibliographic Details

Published in:	mBio
Main Authors:	Annelies Stevaert, Ria Van Berwaer, Cato Mestdagh, Julie Vandeput, Els Vanstreels, Valerie Raeymaekers, Manon Laporte, Lieve Naesens
Format:	Article
Language:	English
Published:	American Society for Microbiology 2022-08-01
Subjects:	SARS-CoV-2 human coronavirus 229E spike protein mutation protease cleavage
Online Access:	https://journals.asm.org/doi/10.1128/mbio.01376-22