Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

The tumor suppressor gene TP53 is inactivated by mutation in a large fraction of human tumors. Around 10% of TP53 mutations are nonsense mutations that lead to premature termination of translation and expression of truncated unstable and non-functional p53 protein. Aminoglycosides G418 (geneticin) a...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Meiqiongzi Zhang, Angelos Heldin, Mireia Palomar-Siles, Susanne Öhlin, Vladimir J. N. Bykov, Klas G. Wiman
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-01-01
Subjects:	p53 nonsense mutation aminoglycosides MDM2 inhibitors readthrough
Online Access:	http://journal.frontiersin.org/article/10.3389/fonc.2017.00323/full