Lactate dehydrogenase A (LDHA)-mediated lactate generation promotes pulmonary vascular remodeling in pulmonary hypertension

Abstract Background High levels of lactate are positively associated with prognosis and mortality in pulmonary hypertension (PH). Lactate dehydrogenase A (LDHA) is a key enzyme for the production of lactate. This study is undertaken to investigate the role and molecular mechanisms of lactate and LDH...

Full description

Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Daiqian Wu, Shuo Wang, Fengxian Wang, Qing Zhang, Zhen Zhang, Xingbing Li
Format:	Article
Language:	English
Published:	BMC 2024-08-01
Subjects:	Pulmonary hypertension Lactate Lactate dehydrogenase A Vascular remodeling Glycolysis
Online Access:	https://doi.org/10.1186/s12967-024-05543-7