PGJ(2) provides prolonged CNS stroke protection by reducing white matter edema.

Few clinically effective approaches reduce CNS-white matter injury. After early in-vivo white matter infarct, NFκB-driven pro-inflammatory signals can amplify a relatively small amount of vascular damage, resulting in progressive endothelial dysfunction to create a severe ischemic lesion. This proce...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	James D Nicholson, Adam C Puche, Yan Guo, Daniel Weinreich, Bernard J Slater, Steven L Bernstein
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Online Access:	http://europepmc.org/articles/PMC3527449?pdf=render