PHD3 inhibits colon cancer cell metastasis through the occludin-p38 pathway

Prolyl hydroxylase 3 (PHD3) hydroxylates HIFα in the presence of oxygen, leading to HIFα degradation. PHD3 inhibits tumorigenesis. However, the underlying mechanism is not well understood. Herein, we demonstrate that PHD3 inhibits the metastasis of colon cancer cells through the occludin-p38 MAPK pa...

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Bibliographic Details

Published in:	Acta Biochimica et Biophysica Sinica
Main Authors:	Li Yuyao, Yuan Tanglong, Zhang Hongwei, Liu Shuting, Lun Jie, Guo Jing, Wang Yu, Zhang Yuying, Fang Jing
Format:	Article
Language:	English
Published:	China Science Publishing & Media Ltd. 2023-10-01
Subjects:	prolyl hydroxylase 3 colon cancer metastasis occludin p38 MAPK
Online Access:	https://www.sciengine.com/doi/10.3724/abbs.2023103