Hydroxyurea Treatment for Sickle Cell Disease
High fetal hemoglobin (HbF) levels inhibit the polymerization of sickle hemoglobin (HbS) and reduce the complications of sickle cell disease. Pharmacologic agents that can reverse the switch from γ- to β-chain synthesis — γ-globin chains characterize HbF, and sickle β-globin chains are present in Hb...
| Published in: | The Scientific World Journal |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2002-01-01
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| Online Access: | http://dx.doi.org/10.1100/tsw.2002.295 |