Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model

A robust immune response is required for resistance to pulmonary tuberculosis (TB), the primary disease caused by Mycobacterium tuberculosis (Mtb). However, pharmaceutical inhibition of T cell immune checkpoint molecules can result in the rapid development of active disease in latently infected indi...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Mohamed Ahmed, Liku B. Tezera, Nicholas Herbert, Mark Chambers, Michaela T. Reichmann, Kievershen Nargan, Henrik Kloverpris, Farina Karim, Mbali Hlatshwayo, Rajhmun Madensein, Munir Habesh, Monjural Hoque, Adrie J.C. Steyn, Paul T. Elkington, Alasdair J. Leslie
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-04-01
Subjects:	tuberculosis pulmonary infection immune checkpoint CD200 receptor innate immunity
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1360412/full