Bio inspired assessment of titanium-organic framework and exosome-constructed p-Synephrine carriage: pursuing the PI3K/mTOR pathway in a simulated periodontitis

Abstract Periodontitis, a chronic inflammatory disease, is driven by bacterial infection and oxidative stress, leading to tissue destruction and potential tooth loss. This study investigates the anti-inflammatory and antioxidant potential of p-Synephrine and enhanced delivery through NH2−MIL-125 and...

Full description

Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Mohamed S. Kishta, Abdelrahman H. Elshaar, Rawan N. Makled, Ghada A. Abdel-Aleem, Mirhan N. Makled, Reda M. Abdelhameed
Format:	Article
Language:	English
Published:	Nature Portfolio 2026-05-01
Subjects:	Periodontitis MIL-125 p-Synephrine Exosomes Dental pulp stem cells (DPSCs)
Online Access:	https://doi.org/10.1038/s41598-026-54070-6