α-Hederin Saponin Augments the Chemopreventive Effect of Cisplatin against Ehrlich Tumors and Bioinformatic Approach Identifying the Role of SDF1/CXCR4/p-AKT-1/NFκB Signaling

Stromal cell-derived factor-1 (SDF1) and its C-X-C chemokine receptor type 4 receptor (CXCR4) are significant mediators for cancer cells’ proliferation, and we studied their expression in Ehrlich solid tumors (ESTs) grown in mice. α-Hederin is a pentacyclic triterpenoid saponin found in Hedera or Ni...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Samah M. Elaidy, Mohamed K. El-Kherbetawy, Sally Y. Abed, Abdullah Alattar, Reem Alshaman, Mohamed Ahmed Eladl, Eman Saad Alamri, Aisha Nawaf Al balawi, AbdelNaser Zaid, Amany Y. Elkazzaz, Sozan M. Abdelkhalig, Ziad E. Hamed, Sawsan A. Zaitone
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Subjects:	α-hederin cisplatin Ehrlich solid tumor mouse SDF1/CXCR4/p-AKT/NFκB signaling
Online Access:	https://www.mdpi.com/1424-8247/16/3/405