Analyses of GWAS and Sub‐Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk

Abstract Schizophrenia (SCZ) is highly polygenic, and its biological underpinnings remain unclear. In this study, a cost‐effective strategy of including sub‐threshold GWAS (subGWAS) loci (i.e., 5 × 10−8 < P ≤ 10−6) in analysis is explored to increase the inference power of novel pathways. A total...

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Bibliographic Details

Published in:	Advanced Science
Main Authors:	Rui Chen, Benjamin Siciliano, Quan Wang, Chongchong Xu, Qiang Wei, Hai Yang, James S Sutcliffe, Yi Jiang, Ying Ji, Chunyu Liu, Feixiong Cheng, Edwin H Cook, Nancy J Cox, Xue Zhong, Zhexing Wen, Bingshan Li
Format:	Article
Language:	English
Published:	Wiley 2025-10-01
Subjects:	dendrite development genetic risk GWAS neurodevelopmental psychiatric disorder Schizophrenia
Online Access:	https://doi.org/10.1002/advs.202508519