The LEDGIN GS-9822 inhibits HIV-2 infection and enhances HIV-2 latency

ABSTRACT HIV integration is targeted toward active transcription units through the interaction of HIV integrase with the cellular co-factor LEDGF/p75. LEDGINs, small molecule inhibitors of this interaction, reduce HIV-1 integration and retarget residual proviruses away from active transcription unit...

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Bibliographic Details

Published in:	Microbiology Spectrum
Main Authors:	Anne Bruggemans, Gerlinde Vansant, Eline Pellaers, Paulien Van de Velde, Frauke Christ, Zeger Debyser
Format:	Article
Language:	English
Published:	American Society for Microbiology 2026-06-01
Subjects:	HIV-1 HIV-2 LEDGIN LEDGF small molecule inhibitor
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.01699-25