Fibroblast Growth Factor Receptor 4 Deficiency Mediates Airway Inflammation in the Adult Healthy Lung?

Fibroblast growth factor receptor (FGFR) 4 has been shown to mediate pro-inflammatory signaling in the liver and airway epithelium in chronic obstructive pulmonary disease. In past reports, FGFR4 knockout (Fgfr4−/−) mice did not show any lung phenotype developmentally or at birth, unless FGFR3 defic...

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Bibliographic Details

Published in:	Frontiers in Medicine
Main Authors:	Molly Easter, Jaleesa Garth, Elex S. Harris, Ren-Jay Shei, Eric S. Helton, Yuhua Wei, Rebecca Denson, Rennan Zaharias, Steven M. Rowe, Patrick Geraghty, Christian Faul, Jarrod W. Barnes, Stefanie Krick
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-07-01
Subjects:	fibroblast growth factor receptor 4 lung inflammation bronchial epithelium interleukin 6 airway surface liquid volume
Online Access:	https://www.frontiersin.org/article/10.3389/fmed.2020.00317/full