Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of CD69 expressing naïve CD4+ T cells

IntroductionSepsis is responsible for 1 in 5 deaths globally and the majority of those who survive have lasting health issues. A hallmark of sepsis is a deregulated inflammatory response to infection, with leukocytes playing a critical role.MethodsThis study utilised a targeted single-cell multi-omi...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Joshua Flynn, Anne Marie Baird, Eamon Breen, Michael Carty, Ciara S. McNevin, Lisa McDermott, Elaine M. Kenny, John Davis Coakley, Thomas Ryan, Derek G. Doherty, Orla Sheils
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	sepsis multi-omic single-cell sequencing immunosuppression cytotoxicity inflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1667186/full