Hyper-N-glycosylated SEL1L3 as auto-antigenic B-cell receptor target of primary vitreoretinal lymphomas

Abstract Primary vitreoretinal lymphoma (PVRL) is a rare subtype of DLBCL and can progress into primary central nervous system lymphoma (PCNSL). To investigate the role of chronic antigenic stimulation in PVRL, we cloned and expressed B-cell receptors (BCR) from PVRL patients and tested for binding...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Michelle Elbert, Frank Neumann, Maximilian Kiefer, Konstantinos Christofyllakis, Benedikt Balensiefer, Igor Kos, Gabi Carbon, Dominic Kaddu-Mulindwa, Joerg Thomas Bittenbring, Natalie Fadle, Evi Regitz, Falko Fend, Irina Bonzheim, Lorenz Thurner, Moritz Bewarder
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-04-01
Subjects:	B-cell receptor antigens Primary vitreoretinal lymphoma SEL1L3 Primary CNS lymphoma SAMD14/neurabin-I Auto-antigens
Online Access:	https://doi.org/10.1038/s41598-024-60169-5