N-Acetylaspartate Drives Oligodendroglial Differentiation via Histone Deacetylase Activation

An unmet clinical goal in demyelinating pathologies is to restore the myelin sheath prior to neural degeneration. N-acetylaspartate (NAA) is an acetylated derivative form of aspartate, abundant in the healthy brain but severely reduced during traumatic brain injury and in patients with neurodegenera...

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Bibliographic Details

Published in:	Cells
Main Authors:	Alessandra Dominicis, Alice Del Giovane, Matteo Torreggiani, Antonella Damiana Recchia, Fabio Ciccarone, Maria Rosa Ciriolo, Antonella Ragnini-Wilson
Format:	Article
Language:	English
Published:	MDPI AG 2023-07-01
Subjects:	remyelination epigenetics histone deacetylases (HDACs) multiple sclerosis (MS) N-acetylaspartate (NAA) neurodegeneration
Online Access:	https://www.mdpi.com/2073-4409/12/14/1861