A large-scale concordance study of toxicity findings across preclinical species and humans for small molecules and biologics

Translating preclinical safety findings into reliable insights for human risk assessment remains a fundamental challenge in drug development. Prior preclinical-clinical concordance studies have been constrained by limited drug coverage, reliance on identical-term matching for adverse events (AEs), a...

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Bibliographic Details

Published in:	Frontiers in Toxicology
Main Authors:	Xin Liu, Fan Fan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2026-04-01
Subjects:	AI-powered decision support clinical safety outcomes concordance analysis mechanistic interpretation preclinical toxicity translational safety
Online Access:	https://www.frontiersin.org/articles/10.3389/ftox.2026.1731947/full