Impact of genetic polymorphisms on the pharmacokinetics and pharmacodynamics of lenvatinib in patients with hepatocellular carcinoma

This prospective study examined the impact of genetic polymorphisms on the pharmacokinetics and clinical efficacy and safety of lenvatinib, a substrate of ATP-binding transporters, in a cohort of 48 Japanese patients with hepatocellular carcinoma (HCC). Pharmacokinetic studies were performed at the...

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Bibliographic Details

Published in:	Journal of Pharmacological Sciences
Main Authors:	Hironao Okubo, Hitoshi Ando, Kei Ishizuka, Jun-ichi Morishige, Kenichi Ikejima, Shuichiro Shiina, Akihito Nagahara
Format:	Article
Language:	English
Published:	Elsevier 2022-01-01
Subjects:	Lenvatinib Pharmacokinetic study Polymorphism Adverse event Hepatocellular carcinoma
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861321000864