Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles

DNA methylation is recognized as one of several epigenetic regulators of gene expression and as potential driver of carcinogenesis through gene-silencing of tumor suppressors and activation of oncogenes. However, abnormal methylation, even of promoter regions, does not necessarily alter gene express...

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Bibliographic Details

Published in:	Epigenetics
Main Authors:	Hagen Klett, Yesilda Balavarca, Reka Toth, Biljana Gigic, Nina Habermann, Dominique Scherer, Petra Schrotz-King, Alexis Ulrich, Peter Schirmacher, Esther Herpel, Hermann Brenner, Cornelia M. Ulrich, Karin B. Michels, Hauke Busch, Melanie Boerries
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2018-04-01
Subjects:	epigenetic regulation colorectal cancer dna methylation gene expression prediction model hmga1
Online Access:	http://dx.doi.org/10.1080/15592294.2018.1460034