Ginsenoside Rh2 shifts tumor metabolism from aerobic glycolysis to oxidative phosphorylation through regulating the HIF1-α/PDK4 axis in non-small cell lung cancer

Abstract Background Ginsenoside Rh2 (G-Rh2), a steroidal compound extracted from roots of ginseng, has been extensively studied in tumor therapy. However, its specific regulatory mechanism in non-small cell lung cancer (NSCLC) is not well understood. Pyruvate dehydrogenase kinase 4 (PDK4), a central...

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Bibliographic Details
Published in:Molecular Medicine
Main Authors: Xiyu Liu, Jingjing Li, Qingqing Huang, Mingming Jin, Gang Huang
Format: Article
Language:English
Published: BMC 2024-04-01
Subjects:
Ginsenoside Rh2
NSCLC
PDK4
Glycolysis
Oxidative phosphorylation
Online Access:https://doi.org/10.1186/s10020-024-00813-y

Internet

https://doi.org/10.1186/s10020-024-00813-y

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