Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA

Abstract Hyperuricemia is associated with an increased risk of gout, hypertension, diabetes, and cardiovascular diseases. Most mammals maintain normal serum uric acid (SUA) via urate oxidase (Uox), an enzyme that metabolizes poorly-soluble UA to highly-soluble allantoin. In contrast, Uox became a ps...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Mengjie Zhang, Abid Hussain, Bo Hu, Haiyin Yang, Chunhui Li, Shuai Guo, Xiaofeng Han, Bei Li, Yunlu Dai, Yuhong Cao, Hang Chi, Yuhua Weng, Cheng-Feng Qin, Yuanyu Huang
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-07-01
Online Access:	https://doi.org/10.1038/s41467-024-50752-9