Proteomic analysis of pleomorphic dermal sarcoma reveals a fibroblastic cell of origin and distinct immune evasion mechanisms

Abstract Pleomorphic dermal sarcomas are infrequent neoplastic skin tumors, manifesting in regions of the skin exposed to ultraviolet radiation. Diagnosing the entity can be challenging and therapeutic options are limited. We analyzed 20 samples of normal healthy skin tissue (SNT), 27 malignant mela...

وصف كامل

التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Scientific Reports
المؤلفون الرئيسيون:	Sebastian Klein, Yuri Tolkach, Hans Christian Reinhardt, Reinhard Buettner, Alexander Quaas, Doris Helbig
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Nature Portfolio 2024-05-01
الموضوعات:	Pleomorphic dermal sarcoma PDS Protein profiling Fibroblastic differentiation Immune escape mechanisms Cutaneous sarcoma
الوصول للمادة أونلاين:	https://doi.org/10.1038/s41598-024-62927-x