Serum coating enables feeder-free culture of naive human pluripotent stem cells preserving developmental potential

Abstract Naive human pluripotent stem cells (hPSCs) represent a pre-implantation epiblast state able to efficiently differentiate into embryonic and extraembryonic pre-implantation lineages and to self-organise in vitro into blastocyst-like structures called blastoids. Naive hPSC maintenance routine...

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發表在:	The EMBO Journal
Main Authors:	Giada Rossignoli, Michael Oberhuemer, Ida Sophie Brun, Irene Zorzan, Anna Osnato, Anne Wenzel, Emiel van Genderen, Andrea Drusin, Giorgia Panebianco, Nicolò Magri, Moritz Becker, Mairim Alexandra Solis, Chiara Colantuono, Sam Samuël Franciscus Allegonda van Knippenberg, Thi Xuan Ai Pham, Sherif Khodeer, Paolo Grumati, Davide Cacchiarelli, Paolo Martini, Nicolas Rivron, Vincent Pasque, Jan Jakub Żylicz, Martin Leeb, Graziano Martello
格式:	Article
語言:	英语
出版:	Springer Nature 2026-03-01
主題:	Human Naive Pluripotent Stem Cells Blastoids Extraembryonic Lineages Extracellular Matrix Feeder-free
在線閱讀:	https://doi.org/10.1038/s44318-026-00714-2