HGF/c-MET axis contributes to CLL cell survival by regulating multiple mechanisms making it a potential therapeutic target for CLL treatment

Despite significant advances in understanding the occurrence, progression and treatment of chronic lymphocytic leukemia (CLL), there remains a need to explore novel mechanisms and therapeutic strategies. In this study, we discovered that hepatocyte growth factor (HGF), a cytokine highly expressed by...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Shihao Liang, Xiaoya Shao, Xueqiong Meng, Ying Cui, Chuanyue Sun, Jie Sun, Binghui Zhang, Guomin Shen, Ling Qin, Haiping Yang, Yixiang Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Subjects:	chronic lymphocytic leukemia HGF/c-Met signaling pathway anti-apoptotic proteins capmatinib
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1612916/full