Pre‐dispositions and epigenetic inheritance in the Escherichia coli lactose operon bistable switch

Abstract The lactose operon regulation in Escherichia coli is a primary model of phenotypic switching, reminiscent of cell fate determination in higher organisms. Under conditions of bistability, an isogenic cell population partitions into two subpopulations, with the operon's genes turned on o...

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Bibliographic Details

Published in:	Molecular Systems Biology
Main Authors:	Lydia Robert, Gregory Paul, Yong Chen, François Taddei, Damien Baigl, Ariel B Lindner
Format:	Article
Language:	English
Published:	Springer Nature 2010-04-01
Subjects:	adaptation bistability differentiation lac operon stochastic gene expression
Online Access:	https://doi.org/10.1038/msb.2010.12