Maternal sevoflurane exposure increases the epilepsy susceptibility of adolescent offspring by interrupting interneuron development

Abstract Background Exposure to general anesthesia influences neuronal functions during brain development. Recently, interneurons were found to be involved in developmental neurotoxicity by anesthetic exposure. But the underlying mechanism and long-term consequences remain elusive. Methods Pregnant...

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Bibliographic Details

Published in:	BMC Medicine
Main Authors:	Xinyue Liang, Ming Jiang, Hao Xu, Tianxiang Tang, Xiangpeng Shi, Yi Dong, Lei Xiao, Yunli Xie, Fang Fang, Jing Cang
Format:	Article
Language:	English
Published:	BMC 2023-12-01
Subjects:	Anesthetic neurotoxicity Epilepsy susceptibility Interneuron tangential migration CXCL12/CXCR4 pathway
Online Access:	https://doi.org/10.1186/s12916-023-03210-0