Low-Molecular Weight Polyethylenimine Modified with Pluronic 123 and RGD- or Chimeric RGD-NLS Peptide: Characteristics and Transfection Efficacy of Their Complexes with Plasmid DNA

To solve the problem of transfection efficiency vs. cytotoxicity and tumor-targeting ability when polyethylenimine (PEI) was used as a nonviral gene delivery vector, new degradable PEI polymers were synthesized via cross-linking low-molecular-weight PEI with Pluronic P123 and then further coupled wi...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Jing Hu, Wenfang Zhao, Kehai Liu, Qian Yu, Yuan Mao, Zeyu Lu, Yaguang Zhang, Manman Zhu
Format:	Article
Language:	English
Published:	MDPI AG 2016-05-01
Subjects:	polycations RGD nuclear localization signal physico-chemical properties transfection efficiency
Online Access:	http://www.mdpi.com/1420-3049/21/5/655