Low-Molecular Weight Polyethylenimine Modified with Pluronic 123 and RGD- or Chimeric RGD-NLS Peptide: Characteristics and Transfection Efficacy of Their Complexes with Plasmid DNA

To solve the problem of transfection efficiency vs. cytotoxicity and tumor-targeting ability when polyethylenimine (PEI) was used as a nonviral gene delivery vector, new degradable PEI polymers were synthesized via cross-linking low-molecular-weight PEI with Pluronic P123 and then further coupled wi...

وصف كامل

التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Molecules
المؤلفون الرئيسيون:	Jing Hu, Wenfang Zhao, Kehai Liu, Qian Yu, Yuan Mao, Zeyu Lu, Yaguang Zhang, Manman Zhu
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	MDPI AG 2016-05-01
الموضوعات:	polycations RGD nuclear localization signal physico-chemical properties transfection efficiency
الوصول للمادة أونلاين:	http://www.mdpi.com/1420-3049/21/5/655