Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies

Protein-based targeted toxins play an increasingly important role in targeted tumor therapies. In spite of their high intrinsic toxicity, their efficacy in animal models is low. A major reason for this is the limited entry of the toxin into the cytosol of the target cell, which is required to mediat...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Hendrik Fuchs, Nicole Niesler, Alexandra Trautner, Simko Sama, Gerold Jerz, Hossein Panjideh, Alexander Weng
Format:	Article
Language:	English
Published:	MDPI AG 2017-03-01
Subjects:	saponins endosomal escape efficacy enhancers targeted toxins immunotoxins cytosolic drug delivery controlled drug release cancer treatment endocytosis
Online Access:	http://www.mdpi.com/2227-9059/5/2/14